DEXAMETHASONE EFFECTS ON SERUM GLUCOSE AND POTASSIUM CONCENTRATIONS AND PLATELET COUNT OF WISTAR RAT
Muhamed Fočak, Edhem Hasković, Damir Suljević, Erna Islamagić
Department of Biology, Faculty of Science, Zmaja od Bosne 33–35, Sarajevo, 71000 Bosnia and Herzegovina
mfocak10@gmail.com
Dexamethasone is synthetic corticosteroide which influences the metabolism of glucose, ion transport in organisms and values of certain hematological parameters. In this research, dexamethasone was applied in musculus gluteus maximus of Wistar rat species in form of dexamethasone phosphate sodium solution in 1 mL ampoules. Each ampoule contains 4 mg of dexamethasone, administered each 24 hours in 4 days period. Glucose and potassium concentrations in serum, and platelet count in whole blood were observed. After the experiment and statistical processing of collected data, it was determined that concentrations of serum glucose and platelet count were significantly increased, while values of serum potassium were significantly decreased, compared with control group.
Keywords: corticosteroids; thrombocytopoiesis; hypokalemia; rats; glucose
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