TOXIC EFFECTS OF CADMIUM, BECAUSE OF CHRONIC EXPOSURE ON REPRODUCTION PARAMETERS OF CAVIA PORCELLUS FEMALES
Albana Munga, Dashamir Xhaxhiu, Dorjana Beqiraj, Jani Mavromati
Agricultural University of Tirana, Faculty of Veterinary Medicine, Tirana, Albania
albanamunga@yahoo.com
Cadmium is a ubiquitous environmental pollutant of increasing worldwide concern. Cadmium accumulation occurs in various tissues and organs, with the most extensive accumulation in kidney cortex. This study analyzes some of cadmium effects on reproduction parameters of the females Cavia porcellus. Cadmium was applied by intraperitoneal injections in doses of 0.0005 mg/kg/day, 0.1148 mg/kg/day and 0.2177 mg/kg/day to the mature female Cavia porcellus. After 60 days, animals were killed and the samples of ovaries were prepared for optic microscope observations. The changes in the ovaries were compared with those of the healthy Cavia porcellus. The hormones secretion profile and cadmium accumulation were monitored weekly by analyzing blood samples. The increasing of Cadmium dose applied results in many pronounced histological damages in the ovary. Among the histological damages recorded were a high number of atretic follicula, arresting of their maturity, disruption of cell contacts, atrophy and disorganization of granulose cells, small corpus luteum with hemorrhagic processes. Increasing cadmium concentration reduces the secretion rate of estradiol (r = ‑0.962), progesterone (r = ‑0.83), FSH (r = ‑0.962), and increases the secretion of testosterone (r = 0.98) and LH (r = 0.697).
Keywords: cadmium; reproduction; ovary; gonadotropins; sexual steroides
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